Frequently Asked Questions (FAQ)

  • Are there any scientific/academic publications on RetroMAD1?

    There are currently no publications. Our current efforts are focused on obtaining marketing authorisation in US (FDA) and in the EU (EMA), but publications are one of the things we will be working on in the near future.

    Where have you successfully shipped RetroMAD to?

    United States, Canada, United Kingdom, Denmark, Italy, Germany, Portugal, Holland, South Africa

    Will RetroMAD1 be shipped to be by cold-chain transport?

    RetroMAD1 will be couriered in normal room temperature conditions, which is absolutely not a problem as it is considered short-term, even if there is a delay in customs.

    What will happen if the package gets held up at customs?

    Different countries have different approaches in the event of a hold up at customs. In general, one or more of the following may occur: the package contents may be inspected/analysed, more information about the package contents and its purpose may be requested by customs from Biovalence or the recipient. There is a small risk of permanent confiscation, in the event the customs are not satisfied with the outcome of their inspection/inquiry. However, based on previous shipping records almost all have been successful.

  • Are there any contraindications with other medication or supplements?

    We are currently unaware of any adverse drug interactions with RetroMAD1. RetroMAD1 has always been administered alongside conventional/supplementary treatment in our trials without any restrictions. It is possible that RetroMAD1 protein’s relatively large size (37kDA) reduces the likehood of unwanted interactions with other drugs.

    My cat is refusing to take RetroMAD1, can I mix it with food to help intake?

    Though RetroMAD1 is odourless and tasteless, in rare cases cats may refuse to take it. In such situations, administering RetroMAD1 with abit of tuna juice or milk is acceptable.

    Do I really have to refrigerate RetroMAD1?

    RetroMAD1 is actually thermostable. It has been shown to retain its antiviral efficacy even when kept at room temperature up to a year. The reason why we strongly encourage refrigeration is to delay the onset of bacterial contamination/growth (thus extending its shelf life), as it is a protein after all. This is particularly important once the bottle has started use.

    How long will the supplied RetroMAD1 last for?

    The supplied RetroMAD1 should be sufficient to last for 3 months, the current intended treatment duration for FIV and FeLV.

    How long should I treat my cat with RetroMAD1?

    After completing a 3-month RetroMAD1 treatment regime, pet owners may choose to discontinue RetroMAD1 treatment if the cat has made a complete recovery of clinical symptoms. They may also opt to continue on with treatment if there is slower recovery of clinical symptoms or just for peace of mind (see post-treatment section).

    RetroMAD1 does not seem to be working?

    While RetroMAD1 is a highly promising drug, please understand that it is not a “miracle” drug; there are some cases who unfortunately do not appear respond to RetroMAD1 treatment. There are many factors beyond the scope of RetroMAD1’s mode of action which can affect the extent and rate of the cat’s recovery.

    Can I increase the dosage of RetroMAD1 if I don’t see improvement?

    Our past trial results are based on a dosing of 0.05ml/kg twice a day. Pet owners may consider increasing this to 0.075 to 0.1ml/kg twice a day should no improvement/disease progression be observed after 2-weeks, keeping in mind that this will accelerate depletion of the supplied RetroMAD1. The increased dosing is still well within safety margins as determined by our target animal safety studies in cats. Any changes in dosing must be documented in the provided scoring form and dated.

  • Will my cat show up as PCR / IFA / ELISA negative after RetroMAD1 treatment?

    Ideally we expect RetroMAD1 to clear/significantly reduce FeLV viremia in the cat by the end of the treatment regime. This should theoretically translate to IFA and ELISA negative results. However, we do not expect PCR negative results because of proviral DNA (viral genetic material that is permanently integrated into host genome), which RetroMAD1 does not target.

    Can I choose to continue with RetroMAD1 treatment after completing the treatment regime?

    Yes pet owners may opt to re-enlist their pet in the trial after completing the treatment regime. The same fees apply.

    Will there be a disease relapse after I discontinue RetroMAD1?

    As a result of integration of viral DNA (provirus) into the host genome, the cat will remain infected with FeLV for life. While RetroMAD1 treatment significantly reduces/clears viremia in the cat’s body, upon discontinuation new viral particles can be synthesized from the proviral DNA, causing a resurgence of viremia (rebound effect). This will be reflected by a reappearance of clinical symptoms, which could be weeks or months after RetroMAD1 discontinuation, depending on the cat. RetroMAD1 treatment can be resumed once again when this happens.

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