Third World Viruses
Biovalence is working on finding a cure for Ebola, Zika and Dengue as Third World viruses that potentially impact the wellbeing societies. These viruses often impact the poor and there is currently no first-line treatment available. Most of the available funding goes towards vaccine development as these are probably the cheapest solutions. However, vaccines are for prevention and there are always those who are infected already in any pandemic before a chance of vaccination. This is where a broad spectrum protein like RetroMAD1 comes in. As it does not require refrigeration, it may be stored and transported cheaply in the Third World. The majority of expenditure on drug development has been biased to First World diseases as they can be sold for many times the price a person from the Third World can ever hope to afford. We hope you will consider supporting our research into developing a cure for Third World viruses. We already have promising results for these 3 viruses and if you are keen on making a donation, we would be more than willing to send you more information. All donations earmarked for a particular cause will not be used for any other.
To many of us, our cat or cats is a member of our family. They may not be able to tell us that they are ill but we can observe often through their behaviour that they are unwell. Cats may be infected by a number of different viruses and we are working on developing protein drugs for your pets. For a small biotech company like ours, it is often an uphill struggle as the pathway to getting a drug ready for registration will cost many millions of dollars per indication (which basically is a disease). At present, we’re working on FeLV, FIPV and FPV and will have to perform many costly trials and validation testing in order to develop what is required for regulatory approval. We hope you can set aside some money to donate to the development of a treatment for these feline viruses. Your donation will be used only for drug developmental costs within your specified interest to the extent that donations for cat-related viruses will not be used for dog-related viruses and vice versa.
Dogs are often thought of as man’s best friends. Their behaviour and temperament is so different from cats that many of us are often either dog-lovers or cat-lovers unless you’re like Ernest Hemingway who was said to have over 90 cats and 16 dogs. We’re mainly working on CPV2 that affects young puppies and present standard of care gives an approximately 50% chance of that puppy pulling through the bouts of diarrhoea that can take its life within a week. With RetroMAD1, we’re shown that we can increase the chances of survival to 80% which is a vast improvement. If you’re a dog-lover and wish to donate towards the development of a treatment for CPV2 and possibly other canine viral diseases in the future, please contribute to our cause. Almost every animal drug was previously developed as a regulated approved human drug first before its use was transferred to animals. We’re doing the opposite by getting it into animal use before human use. This however means many regulatory hurdles that are costly. Also, being a protein drug, it is classified as a biologic and there are many additional costs for us to bear in the developmental stages. As in the other categories, all donations will be used strictly to cover drug developmental costs only.
Eutrophication of water bodies
Ammonia is a major pollutant of water bodies coming from industrial and agricultural run-offs and effluents. It is broken down to nitrites and nitrates by different types of bacteria. However, whether it is in the form of ammonia, nitrites or nitrates, these nitrogen compounds all contribute towards eutrophication or the man-induced enrichment of water bodies with excess nitrogen and/or phosphorus (in the form of phosphates). There has been much emphasis on Global Warming in recent times and rightly so but we should not neglect our water bodies too – the ponds, lakes and rivers as well as coastal estuaries. This is because eutrophication leads to an increase in the incidence of blooms of dinoflagellate algae (usually termed as Red Tide) or in sudden blooms of Blue-Green filamentous algae that when they die release various toxins into the environment that may even end up in our drinking water supply. Biovalence is now working on the selection of special naturally occurring bacteria that can change all these pollutants into harmless nitrogen gas which goes directly into the atmosphere. If you feel you wish to contribute towards helping develop clean technologies towards a cleaner environment, this is a great opportunity. All donations will be used to cover direct developmental costs. In this case, it will go towards necessary equipment and lab consumables.