Advanced Technology of Aquaculture Disease Management

B11 Probiotic Bacteria

Biovalence Sdn. Bhd. is a strategic partner and R&D service provider for Blue Archipelago Berhad, Malaysia’s largest shrimp farming initiative. Together, we have set up a Shrimp Disease Centre (commenced operation on 15 April 2015) and are developing practical disease mitigation strategies for major shrimp diseases such as Early Mortality Syndrome (EMS) / Acute Hepatopancreatic Necrosis Disease (AHPND).

Biovalence has successfully isolated a strain of naturally-occurring marine bacteria (B11) which is capable of inhibiting EMS-causing pathogens. B11 can reduce mortality by 90-100% during lab-scale EMS challenge infections. We are currently developing a process to enable upscale production of bacterial endospores. We are now developing pipeline candidates to continue the battle against EMS in the event the pathogen develops resistance to B11.

The Chief Technology Officer of Biovalence, Mr Ung Eng Huan has presented in several aquaculture conferences and workshops on EMS / AHPND, including:


  • Plenary presentation ‘The Complete Story of EMS/AHPND? From Mechanism of Action to Prevention Using Feed’ at The Aquaculture Roundtable Series (TARS) – ‘Shrimp Aquaculture and The New Normal’ in Phuket, Thailand.

    Click here to download the PDF Presentation

  • Presentation ‘ZOT-proteins occur in conjunction with E-family virulence factors in AHPND-causing Vibrio parahaemolyticus associated with either of three prophage elements in their genome’ at the 9th Symposium on Diseases in Asian Aquaculture (DAA9) in Ho Chi Minh City, Vietnam.

  • The Malaysian Society of Marine Sciences (MSMS)-University of Malaya Institute of Ocean & Earth Sciences (IOES) EMS Workshop II at University of Malaya, Kuala Lumpur, Malaysia.

  • Presentation ‘Differences Between EMS/AHPND-Causing Vibrio parahaemolyticus Strains and Its Implications in Controlling Outbreaks’ at World Aquaculture Adelaide 2014 by the World Aquaculture Society (WAS) in Adelaide, Australia.

  • The Malaysian Fisheries Society (MFS) Conference – ‘EMS Mechanism of Bacterial Infection’ at University Putra Malaysia, Serdang, Malaysia.

  • The Malaysian Society of Marine Sciences (MSMS)-University of Malaya Institute of Ocean & Earth Sciences (IOES) EMS Workshop at University of Malaya, Kuala Lumpur, Malaysia.

  • 1-day seminar on shrimp disease by Society of Professional Aquaculture in Chennai, India.

We welcome potential investors, commercialisation partners, and scientific collaborators to get in touch with our team. Please contact Tiffany Coney Ung (tiffany.ung{at}